How Your Body Controls Breathing

Reviewed by Dr C. J. Odike, MRCGP · July 2026

You have never had to remember to breathe, not even while asleep, yet you can also hold your breath or speak in long sentences whenever you choose. Something in your brain is quietly setting the pace. It is not watching the thing you might expect.

Breathing is unusual among the body's automatic processes because it runs constantly without your input, yet you can also take deliberate control of it whenever you like. Both of these things are true because of how the system controlling it is built. A control centre in the brainstem Deep in the brainstem, the lowest part of the brain, sits a cluster of nerve cells that acts as the body's breathing control centre. It fires off a steady rhythm of signals, travelling down the spinal cord to the diaphragm and intercostal muscles, telling them when to contract. This happens continuously, including while you sleep, without any conscious decision required. What the control centre is actually watching It would be reasonable to assume this control centre is monitoring oxygen levels, since oxygen is what breathing ultimately delivers. In fact, its main trigger is different. The control centre is most sensitive to carbon dioxide, the waste gas your body produces and needs to breathe out. As carbon dioxide builds up in the blood, it is detected and the control centre increases the rate and depth of breathing to clear it. Oxygen levels are also monitored, but usually only become the dominant trigger once they have dropped quite low. This is a slower and less sensitive backup system. Why carbon dioxide, not oxygen, leads This arrangement makes sense once you see what each gas signals. Carbon dioxide rises quickly and predictably the moment your body's activity increases, making it a fast, reliable early warning signal that more breathing is needed. Oxygen levels, by contrast, can stay near normal for some time even as a problem develops, making them a much less responsive trigger to build the main system around. Why you cannot hold your breath indefinitely This also explains why holding your breath always ends the same way. As you hold it, carbon dioxide steadily builds up in your blood. Once it crosses a certain threshold, the drive to breathe becomes overwhelming, regardless of how determined you are to keep holding it. You can delay a breath, but the control centre eventually overrides the decision. The parts you can control Despite all this automation, you clearly have some say over your breathing. You can hold your breath, breathe faster or slower on purpose, or shape your breath carefully enough to speak in long, controlled sentences. Higher brain centres, above the brainstem, can temporarily override the automatic rhythm for these voluntary actions. This override is temporary and limited, which is exactly why the automatic system always eventually reasserts control. What a doctor checks A doctor examining someone's breathing pattern is partly checking whether this control system is working normally. Rate and rhythm. A doctor counts the respiratory rate and notes whether breathing is regular or irregular. Certain irregular patterns can point toward a problem with the brainstem's control centre itself, rather than the lungs. Response to illness. A faster breathing rate during infection or illness often reflects the control centre appropriately responding to increased carbon dioxide production, rather than a problem with the lungs themselves. Level of consciousness. Because higher brain centres can influence breathing, a doctor also considers conscious level alongside breathing pattern, since some conditions affecting the brain can change both together. When this system is affected Certain medications, brain injuries, and some conditions affecting the brainstem directly can disrupt this control system rather than the lungs themselves. This can produce an abnormal breathing pattern, even when the lungs are healthy. Breathing changes linked to conscious level are explored further in the lesson "Confusion and Memory Changes".

A control centre in the brainstem sets your breathing rate automatically, driven mainly by rising carbon dioxide rather than falling oxygen, though you can briefly override it on purpose.

Medical words made simple

Brainstem
The lowest part of the brain, connecting it to the spinal cord, which contains the control centre that sets automatic breathing.
Carbon dioxide
A waste gas produced by the body that breathing removes, and the main signal that tells the brainstem to increase breathing.
Respiratory rate
The number of breaths taken per minute, one of the measurements a doctor checks when assessing breathing.
Voluntary breathing
Breathing that is temporarily and deliberately controlled, such as holding your breath or speaking in long sentences, overriding the automatic rhythm briefly.

Quick recap

  • A control centre in the brainstem sends a continuous, automatic rhythm of signals that sets your breathing rate.
  • The main trigger for this control centre is rising carbon dioxide, not falling oxygen.
  • Carbon dioxide is a faster, more reliable early warning signal than oxygen, which is why the main system is built around it.
  • Holding your breath always ends because carbon dioxide keeps building up until the drive to breathe becomes overwhelming.
  • Higher brain centres can briefly override automatic breathing for voluntary actions like speaking, but the override is temporary.
  • A doctor examining breathing pattern is partly checking whether this control system, not just the lungs, is working normally.