Chest Pain: What Could It Be?

Reviewed by Dr C. J. Odike, MRCGP

Chest pain is a symptom, not a diagnosis. Words such as sharp, burning, tight or heavy can guide questions, but none safely identifies the cause. Some dangerous conditions can feel mild or resemble indigestion.

Chest pain is a symptom, not a diagnosis Chest pain can come from several structures in and around the chest. The heart, lungs, pleura, chest wall, oesophagus, nerves and skin can all produce pain or discomfort. The same cause can feel different between people. Different causes can also feel surprisingly similar. A description is therefore one clue within a wider assessment, not a reliable label. Pain words provide clues, not proof Clinicians ask whether the feeling is pressure, tightness, burning, aching or a sharp pain. They also ask where it started, whether it spreads and how long it lasts. Heavy or squeezing discomfort can occur with reduced blood flow to heart muscle. However, a heart attack may also feel like burning or indigestion. Sharp pain that worsens with breathing or coughing is called pleuritic pain. It can occur with pleurisy, pneumonia, a pulmonary embolism, a pneumothorax, pericarditis or chest wall pain. Pain linked to meals or lying down may support reflux. Pain linked to movement, injury or a tender area may support musculoskeletal pain. Neither pattern proves the cause. The main groups of possible causes Heart and circulation causes include angina and acute coronary syndrome. Acute coronary syndrome includes unstable angina and heart attacks caused by a sudden reduction in coronary blood flow. Lung and pleural causes include infection, inflammation, pulmonary embolism and pneumothorax. These may cause breathlessness, cough, fever, coughing up blood or pain that changes with breathing. Chest wall causes include muscle strain, rib injury and inflammation where ribs join the breastbone. Skin or nerve conditions, including shingles, can also cause chest pain. Digestive causes include reflux and other oesophageal problems. Anxiety or panic can produce real chest pain and physical symptoms, but stress alone does not establish the diagnosis. Urgency comes from the whole pattern A clinician considers the timing, duration, triggers, associated symptoms and medical background together. No single word or tender spot safely separates dangerous from harmless causes. Features raising concern include ongoing chest pressure, pain spreading to an arm, neck, jaw, back or stomach, sweating, nausea, light headedness, breathlessness or collapse. Sudden severe breathlessness, coughing up blood or a very fast heartbeat can also suggest a serious lung problem. Not every dangerous condition follows a textbook pattern. Acute coronary syndrome does not always present as central crushing pain. Symptoms and examination add different clues The clinician asks when the pain began, how long each episode lasts and whether it occurs with physical activity, breathing, movement, meals or rest. They ask about breathlessness, sweating, nausea, fainting, palpitations, cough, fever, injury and leg symptoms. They also consider cardiovascular risk, previous heart or lung disease, recent surgery, immobility, pregnancy, medicines and previous episodes. These details change probability but do not confirm a diagnosis. Examination may include pulse, blood pressure, breathing rate, oxygen saturation and temperature. The clinician listens to the heart and lungs and may examine the chest wall, circulation and legs. Reproducing the pain by pressing one area makes a chest wall cause more likely. It does not safely exclude acute coronary syndrome or another serious cause on its own. Tests answer specific questions An ECG records the heart's electrical activity. It may show patterns suggesting reduced coronary blood flow, a heart attack, a rhythm problem or an older injury. A normal first ECG does not exclude acute coronary syndrome. Clinicians interpret it with what the person describes, the examination and sometimes repeated ECGs. Troponin is a protein released when heart muscle is damaged. The level, timing and change between samples help assess possible heart attack. A detectable or raised troponin does not identify the cause by itself. Other conditions can also injure heart muscle, so the clinical context remains essential. A chest X ray may help find pneumonia, pneumothorax or fluid in the lungs. It does not rule out acute coronary syndrome and cannot reliably exclude a pulmonary embolism. Other tests depend on the suspected cause. These may include blood tests, CT imaging or tests for stable angina after urgent conditions have been addressed. What happens after urgent causes are considered If emergency causes become less likely, the differential diagnosis may shift towards musculoskeletal pain, reflux, infection, anxiety or another explanation. Treatment then depends on the supported cause. A less dangerous explanation should not be chosen only because the person is young, stressed or has chest wall tenderness. The complete pattern still matters. When to get help Call 999 for sudden chest pain or discomfort that does not go away. This includes pressure, squeezing, burning or a feeling like indigestion. Call 999 if pain spreads to either arm, the neck, jaw, stomach or back. Also call if chest pain occurs with sweating, nausea, light headedness or shortness of breath. Call 999 for severe breathing difficulty or if someone collapses and is not responding normally. Do not drive yourself to A&E. Chest pain that comes and goes, or settles quickly but still worries you, needs medical advice. Do not use this lesson to diagnose or triage an individual episode.

Chest pain cannot be diagnosed from one descriptive word, trigger, tender spot or test. Safe assessment combines the full symptom pattern, risk context, examination and investigations, with direct emergency action when concerning features are present.

Medical words made simple

Acute coronary syndrome
A group of urgent conditions caused by a sudden reduction in blood flow through the heart's coronary arteries. It includes unstable angina and heart attack.
Angina
Chest discomfort caused by temporarily reduced blood flow to heart muscle. It is often triggered by physical activity, but the pattern needs clinical assessment.
ECG
A recording of the heart's electrical activity. It can provide important clues, but a normal ECG does not exclude every serious heart problem.
Troponin
A protein released into blood when heart muscle is damaged. Its level and change over time are interpreted with symptoms and ECG findings.
Musculoskeletal pain
Pain arising from muscles, ribs, joints or cartilage. Movement or tenderness may support this cause but does not prove it.
Reflux
Stomach contents moving back into the oesophagus, often causing burning discomfort. Similar discomfort can also occur with heart problems.
Pleuritic pain
Sharp pain that worsens with breathing or coughing. It describes a pattern and does not identify one specific cause.
Pulmonary embolism
A blood clot blocking an artery in the lungs. It may cause breathlessness, chest pain, a fast heartbeat, coughing up blood or collapse.
Pneumothorax
Air trapped between a lung and the chest wall, causing part or all of the lung to collapse. It can cause sudden pain and breathlessness.
Differential diagnosis
The set of possible causes a clinician considers and updates as more information becomes available.

Quick recap

  • Chest pain can arise from the heart, lungs, chest wall, oesophagus, nerves or skin.
  • Sharp, burning, heavy or tender pain provides clues but does not confirm the cause.
  • Ongoing or spreading chest pain with sweating, nausea, light headedness or breathlessness requires calling 999.
  • Chest wall tenderness supports a musculoskeletal cause but does not safely exclude acute coronary syndrome.
  • A normal first ECG does not exclude acute coronary syndrome, and troponin indicates injury rather than its cause alone.
  • Safe assessment combines timing, associated symptoms, risk context, examination and targeted tests.